
Slade has produced and/or mixed recordings by such artists as Hole, Warren Zevon, Pixies, The Lemonheads, Juliana Hatfield, Morphine, Big Dipper, Dinosaur Jr., HumanKind, Uncle Tupelo, Tracy Bonham, Spacehog, the Mighty Mighty Bosstones, Suddenly, Tammy!, Lou Reed, The Boo Radleys, New Collisions, Sebadoh, Lush, the Go-Go's, The Dictators, Beth Sorrentino, Weezer, Kim Boekbinder, The Dresden Dolls, Echobelly, Buffalo Tom, and Papas Fritas. The song initially failed to achieve commercial success, but after the album release in early 1993, "Creep" was re-released and became a worldwide hit.

They were pivotal in convincing EMI Records to release " Creep" as the band's debut single prior to the album's release. Slade and Kolderie co-produced Radiohead's debut album, Pablo Honey, which was released 1993. He played rhythm guitar and occasionally sang and wrote songs for the Boston indie band Men & Volts, which also included Kolderie. Slade remained active as a musician in the 1980s. The plan was, 'Get a control room, get a playing room, get the wiring right, get a console, and then just start recording'." "The whole idea of getting someone in to design wasn’t part of the plan. "We were all a part of that DIY kind of culture," said Slade. The studio originated in Roxbury, but later relocated to Cambridge, Massachusetts. In 1985, Slade and Kolderie co-founded Boston's Fort Apache Studios, along with Jim Fitting (another friend from Yale and Sex Execs) and Joe Harvard. As Kolderie recalled, they learned a lot from the engineers there.
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As Sex Execs became more successful, they started recording in professional studios such as Syncro Sound, which was owned by The Cars. Other bands came over to record as well, including a local act called Three Colors, which featured saxophonist Dana Colley, later of Morphine. In a 2018 interview, Slade discussed how their career as producers got started at that house with a four-track reel-to-reel recorder they had bought in New York. Most of the group lived in a house in Dorchester, Boston that was wired up as a primitive studio. The duo had their formative experience as producers while they were in Sex Execs. They both later relocated to Boston, where they became members of Sex Execs, a new wave music band of the early 1980s.

Slade and Kolderie became friends at Yale, where they played in bands together. He graduated from Yale University in 1978. Slade was born in Lansing, Michigan, United States. On many of his productions he worked in partnership with Paul Q. His latest works are the co-authored ASCD publication School Climate Change: How Do I Build a Positive Environment for Learning?, and the co-edited Routledge publication Integrating Prosocial Learning with Education Standards.Sean Slade (born 14 November 1957) is an American record producer, engineer, and mixer. He has been a regular guest columnist for both the Huffington Post and The Washington Post commenting on areas of school reform that relate to education, health, well-being, resilience and school climate. Slade has written extensively on topics related to the Whole Child, health and well-being and seeks to shift public dialogue about education from a purely academic focus to a whole child approach that encompasses all factors required for successful student outcomes. He has over 25 years of experience in education and his career has encompassed 4 continents and 5 countries.

Sean Slade is the Senior Director of Global Outreach at Association for Supervision and Curriculum Development (ASCD), focusing on promoting and expanding the ASCD Whole Child approach across the United States and globally.
